The jury is still out on this one but if you choose to TPA, consider closely following the ECASS' inclusion criteria:
Of particular note, super young, super old and major strokes were excluded.
Source
Hacke, W MD et al. "Thrombolysis with Alteplace 3 to 4.5 hours after Acute Ischemic Stroke." NEJM. 25 Sept 2008. v 359. n 13.