Coumadin is how many times more effective than aspirin at preventing stroke from atrial fibrillation?

About 3x. Warfarin prevents 62% of strokes and asprin prevents 22%. How these relative risk reductions translate into absolute benefit depends on the underlying risk for stroke.

Source

Gage, B. MD. et al. "Warfarin Therapy for an Octogenarian Who Has Atrial Fibrillation." Ann Intern Med. 2001; 134:465-474.
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