A rare but don't-want-to-miss cause of pediatric extremity pain: acute lymphoblastic leukemia. What are some clinical clues?

• fever
• lymphadenopathy
• testicular enlargement
• mediastinal mass
• peripheral blood abnormalities: anemia and/or thrombocytopenia

Source

Horton, T. MD and Steuber, P. MD "Overview of the presentation and classification of acute lymphoblastic leukemia in children" Up to Date. 5 Feb 2008.