Name three metabolic abnormalities that can ensue after initiation of spironolactone (aldactone)? What is the mechanism?

1. Hyperkalemia
2. Hyponatremia
3. Metabolic acidosis



Mechanim: Spironolactone blocks aldosterone at its receptor sites in the distal renal tubules, increasing sodium excretion while conserving potassium and hydrogen ions.


Source

Spironolactone: Drug information. Lexi-Comp.