Which steroid is best for treating elevated intracranial pressure secondary to brain cancer/mets? Why?

Dexamethasone. It is the most lipid soluble of all the steroids and hence can cross the blood-brain barrier.


Source

Halfdanarson, T. et al. "Oncologic Emergencies: Diagnosis and Treatment" Mayo Clin Proc. 2006 June (LLSA Readings 2009)