Name a treatment option for cold induced ischmic limb injury which is not responding to active rewarming measures.

Intravenous or intraarterial thrombolytic therapy has been reported in two retrospective studies to reduce the rate of major amputation.


Source

Sheridan, R. et al. "Case 41-2009: A 16-Year-Old Boy with Hypothermia and Frostbite" N Engl J Med 31 Dec 2009.