Tenofovir-emtricitabine (Truvada) or Zidovudine-lamivudine (Combivir) ... which is the better two-drug regimen for HIV prophylaxis?

Truvada.

Similar cost.

Similar efficacy.

Once daily dosing versus BID.

Less side effects, potential nephrotoxicity, versus a multitude of side effects (nausea, asthenia, neutropenia, anemia, abnormal liver enzyme levels)


Source

Chin, R. "Postexposure Prophylaxis for HIV"  Emerg Med Clin N Am.  2010.