- Cancer metastasizes to a vertebral body which subsequently erodes and encroaches on the spinal cord (most common mechanism).
- A cancer occupying the paraspinous space may enter the spinal canal through the intervertebral foramen and subsequently cause cord compression.
- Cancer occurs directly at the spinal cord or meninges.
Source
Halfdanarson, T. et al. "Oncologic Emergencies: Diagnosis and Treatment" Mayo Clin Proc. 2006 June (LLSA Readings 2009)