Yes but it's rare. If a patient > 20 y/o presents with palpable purpura to the lower extremities, it is more likely to be a hypersensitivity vasculitis whereby immune complexes are deposited in venules as a result of infections, drugs, neoplasms, autoimmune connective tissue disease, or dysproteinemias. Treatment is with prednisone +/- antibiotics, for patients in whom this vasculitis follows a bacterial infection. Other disease entities to include in the differential include thrombocytopenic purpura, DIC, septic vasculitis (rickettsial spotted fevers), septic emboli (infective endocarditis), bacteremia (disseminated gonococcal infection, meningococcemia) and other vasculitides.
Source
Fitzpatrick's Color Atlas & Synopsis of Clinical Dermatology
Image source: http://www.hdcn.com/symp/lund/jtimg26.jpg
