- allergy in patients with sulfa sensitivity
- permanent silver staining of the skin and therefore should not be used on the face or other cosmetically sensitive areas
- severe hemolysis in patients with G6PD
- sulfonamide kernicterus in children less than 2 months and therefore should be avoided in pregnant women, newborns and nursing mothers
Hall, R., Watts, L., and Bashiti, S. "Thermal Burns" Critical Decisions in Emergency Medicine. March 2012.