- hypotension out of proportion to the severity of illness
- other clinical features suggestive of primary adrenal insufficiency (where hemodynamic collapse is most prominent secondary to both cortisol and aldosterone depletion) include hyperkalemia, hyponatremia, non-anion gap acidosis, hyperpigmentation and hypoglycemia.
Hydrocortisone dose is 100 mg IV for adults and 1 - 3 mg/kg IV for children.
Burgess, B. and Roe, J. "Adrenal Insufficiency" Critical Decisions in Emergency Medicine. July 2012.