I found this interesting study concerning the effects of smoking on the anti-platelet activity of clopidogrel and it was found that in smoker, the anti-platelet activities of clopidogrel is enhanced!! Reference:Bliden KP et al. The association of cigarette smoking with enhanced platelet inhibition by clopidogrel. J Am Coll Cardiol 2008 Aug 12; 52:531.The association of cigarette smoking with