The Use of Mannitol in Acute Traumatic Brain Injury

Mannitol has been widely used to reduce intracranial pressure (ICP) as early as the 1960s, classically thought to be due to its hyperosmotic action to draw water from the edematous brain. This osmotic property usually takes effect in 15-30 minutes when it sets up an osmotic gradient and draws water out of neurons.However, it was subsequently shown that there was actually less correlation between